Related Experiment Video
Updated: May 9, 2026
09:20
Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS
Published on: August 10, 2017
Identification of novel HDAC inhibitors through cell based screening and their evaluation as potential anticancer
Tong Wang1, Mario Sepulveda, Paul Gonzales
1Translational Drug Development, Inc, 13208 E Shea Boulevard, Suite 100, Scottsdale, AZ 85259,USA. twang@td2inc.com
Bioorganic & Medicinal Chemistry Letters
|August 3, 2013
Abstract:
A series of benzimidazole based HDAC inhibitors have been rationally designed, synthesized and screened. The SAR of this new chemotype is described. The lead compound, 11e, showed strong activity in several cellular assays and demonstrated in vivo efficacy in mouse xenograft pancreatic cancer models.
