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Is mesenteric panniculitis truely a paraneoplastic phenomenon? A matched pair analysis
Ö Gögebakan1, T Albrecht, M A Osterhoff
1Vivantes Klinikum Neukölln, Department for Radiology and Interventional Therapy, Berlin, Germany.
European Journal of Radiology
|August 3, 2013
Summary
Mesenteric panniculitis (MP) is not linked to cancer or other diseases, contrary to prior beliefs. This study found no increased malignancy risk in patients diagnosed with MP.
Area of Science:
- Gastroenterology
- Radiology
- Oncology
Background:
- Mesenteric panniculitis (MP) is an inflammatory condition affecting mesenteric adipose tissue.
- Previous research suggested a potential link between MP and malignancy.
- This study aimed to re-evaluate the association between MP and cancer.
Purpose of the Study:
- To conduct the first matched case-control study on mesenteric panniculitis.
- To compare the prevalence of malignancy in patients with and without MP.
- To investigate associations between MP and other diseases.
Main Methods:
- A keyword search identified CT scans of MP patients from 2010-2012.
- MP patients were matched with two control patients based on age, gender, abdominal diameter, and CT protocol.
- Independent investigators classified MP manifestation and extent; concomitant diseases and follow-up CTs were analyzed.
Main Results:
- The prevalence of MP was 0.58% (77 out of 13,485 CT patients).
- Malignancy was present in 50.6% of MP patients versus 60.2% of controls (p=0.157).
- No association was found between MP development and tumor progression over 4 years; no significant difference in common comorbidities was observed.
Conclusions:
- Mesenteric panniculitis is not associated with malignancy.
- MP is not a paraneoplastic syndrome.
- Contrary to prior reports, MP is not linked to other diseases.