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Related Experiment Video

Updated: May 9, 2026

An Automated Squint Method for Time-syncing Behavior and Brain Dynamics in Mouse Pain Studies

An Automated Squint Method for Time-syncing Behavior and Brain Dynamics in Mouse Pain Studies

Published on: November 1, 2024

Migraine: mimics, borderlands and chameleons.

Heather Angus-Leppan¹

¹Department of Neurology, Barnet and Royal Free Hospitals, London, UK. heather.angus-leppan@nhs.net

Practical Neurology

|August 3, 2013

Summary

Migraine diagnosis is complex, often involving challenging symptoms beyond headache like aura, prodrome, and postdrome. Differentiating migraine from other conditions requires careful patient history to identify its varied presentations.

Area of Science:

Neurology
Clinical Diagnosis

Background:

Headache is a primary symptom of migraine, but associated phenomena like aura, prodrome, and postdrome present diagnostic challenges.
Migraine's complex presentation can be mistaken for other neurological conditions, complicating accurate diagnosis.

Purpose of the Study:

To examine the definition and variants of migraine.
To differentiate migraine from its mimics and borderland conditions.
To explore chameleon presentations of migraine that resemble other diseases.

Main Methods:

Review of migraine definitions, variants, and differential diagnoses.
Analysis of conditions mimicking migraine and those overlapping with other pathologies.
Examination of atypical migraine presentations.

Keywords:

Cerebrovascular Disease Epilepsy Migraine

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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

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Main Results:

Migraine is more frequently a 'chameleon' (presenting as other conditions) than a 'mimic' (being mistaken for migraine).
A thorough patient history is crucial for distinguishing migraine from other diagnoses.
Uncommon migraine features occur frequently due to migraine's high prevalence (10-15%).

Conclusions:

The complex and varied nature of migraine necessitates a detailed diagnostic approach.
Understanding migraine's chameleon-like presentations is key to accurate diagnosis and management.
Even rare migraine presentations should be considered in differential diagnoses due to the condition's prevalence.