Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Caffeine-induced behavioural stimulation is dose- and concentration-dependent.

G B Kaplan1, N T Tai, D J Greenblatt

  • 1Department of Psychiatry, Tufts University School of Medicine, Boston, MA.

British Journal of Pharmacology
|July 1, 1990
PubMed
Summary

Caffeine

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to diazepam in sons of alcoholics.

Alcoholism, clinical and experimental research·1992
Same author

Benzodiazepine receptor binding of nonbenzodiazepines in vivo: alpidem, zolpidem and zopiclone.

Brain research bulletin·1992
Same author

Mental illness, pharmacotherapy, and automobile operation: what is the risk?

Journal of clinical psychopharmacology·1992
Same author

Bioavailability studies of drugs with nonlinear pharmacokinetics: I. Tracer dose AUC varies directly with serum concentration.

Journal of clinical pharmacology·1992
Same author

Pharmacokinetics and preliminary observations of behavioral changes following administration of midazolam to dogs.

Journal of veterinary pharmacology and therapeutics·1992
Same author

Fluoxetine impairs clearance of alprazolam but not of clonazepam.

Clinical pharmacology and therapeutics·1992

Area of Science:

  • Pharmacology
  • Neuroscience
  • Behavioral Science

Background:

  • Caffeine is a widely consumed psychoactive stimulant.
  • Understanding caffeine's dose-dependent effects on behavior and its concentration in plasma and brain is crucial.

Purpose of the Study:

  • To investigate the relationship between plasma and brain caffeine concentrations and behavioral stimulation over time.
  • To determine the kinetic variables of caffeine at different doses in mice.

Main Methods:

  • CD-1 mice received single intraperitoneal doses of caffeine-sodium benzoate (0, 20, 40 mg/kg).
  • Behavioral activity was monitored, and plasma/brain caffeine concentrations were measured using high-performance liquid chromatography (HPLC).

Main Results:

  • Low-dose caffeine (20 mg/kg) initially stimulated vertical behaviors more than high-dose (40 mg/kg).
  • Both doses equally stimulated horizontal and stereotypic behaviors initially, with high-dose showing greater stimulation later.
  • Maximal stimulant effects occurred at intermediate caffeine concentrations (10-20 µg/g).

Conclusions:

  • Caffeine's behavioral effects are concentration-dependent, with an optimal range for stimulation.
  • High doses of caffeine may lead to reduced stimulation or activity decrements at later time points.
  • Kinetic variables like volume of distribution and brain half-life differed significantly between low and high caffeine doses.

Related Experiment Videos