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Elimination pathways of cyclosarin (GF) mediated by β-cyclodextrin in vitro: pharmacokinetic and toxicokinetic

Andreas Kranawetvogl1, Jan Schüler, Susanne Müller

  • 1Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany.

Toxicology Letters
|August 3, 2013
PubMed

Keywords:
BCBC(H)BC(H)(2+)BC(TRIS)CDCHMPCHMPACyclosarinDetoxificationESI/MSGFISLVIMCMC(H)MC(H/NH4)(2+)MC(TRIS)MRMMetabolismNerve agentsO-(1,2,2-trimethylpropyl)methylphosphonic acidO-cyclohexylmethylphosphonateO-cyclohexylmethylphosphonic acidOPOrganophosphorus compoundsPMPARVCTRISbinary (CHMP)(2)-β-CD conjugatebinary adduct of β-CD and CHMP bearing a proton in positive ESI/MSbinary adduct of β-CD and CHMP bearing a protonated TRIS molecule in positive ESI/MS.binary adduct of β-CD and CHMP bearing two protons in positive ESI/MScyclodextrincyclosarinelectrospray ionization mass spectrometryinternal standardlarge volume injectionmono CHMP-β-CD conjugatemono adduct of β-CD and CHMP bearing a proton and another ammonium ion in positive ESI/MSmono adduct of β-CD and CHMP bearing a proton in positive ESI/MSmono adduct of β-CD and CHMP bearing a protonated TRIS molecule in positive ESI/MSmultiple reaction monitoringorganophosphorus compound(s)rotation vacuum concentratortris(hydroxymethyl)aminomethaneβ-CDβ-Cyclodextrinβ-cyclodextrin

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