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Updated: May 9, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
Research on vaccines during pregnancy: reference values for vital signs and laboratory assessments
Jeanne S Sheffield1, Flor M Munoz, Richard H Beigi
1Department of Obstetrics and Gynecology, Division Maternal-Fetal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. jeanne.sheffield@utsouthwestern.edu
Abstract:
The Division of Microbiology and Infectious Diseases at the National Institute of Allergy and Infectious Diseases, National Institutes of Health organized a series of conferences, "Enrolling Pregnant Women in Clinical Trials of Vaccines and Therapeutics", to discuss enrollment and safety assessments of pregnant women in clinical trials of vaccines. Experts in obstetrics, maternal-fetal medicine, infectious diseases, pediatrics, neonatology, genetics, vaccinology and clinical trial design were charged with identifying normal ranges for vital signs and laboratory assessments in pregnancy. A grading system for adverse events was then developed.
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