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Non-invasive Assessment of Microvascular and Endothelial Function
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Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

The correlation between preputial blood flow and microvessel density in distal hypospadias: a prospective clinical

Levent Ceyhan1, Mustafa Cagri Savas1, Sirin Baspinar2

  • 1Department of Pediatric Surgery, Süleyman Demirel University Medical School, Isparta 32260, Turkey.

Journal of Pediatric Urology
|August 3, 2013
PubMed

Insights

This study found no correlation between preputial microvessel density and blood flow in children with hypospadias. Reduced microvessel density did not impact blood flow in the prepuce.

Area of Science:

  • Urology
  • Pediatric Surgery
  • Vascular Biology

Background:

  • Hypospadias is a congenital condition affecting male genitalia.
  • Microvessel density (MVD) and blood flow (BF) are critical for tissue health.

Purpose of the Study:

  • To investigate the relationship between preputial microvessel density and blood flow in children with distal hypospadias.
  • To determine if reduced MVD in hypospadias affects preputial BF.

Main Methods:

  • Prospective study of 44 children (16 hypospadias, 28 controls).
  • Preputial BF measured by laser Doppler flowmetry.
  • Preputial MVD assessed via CD31 immunostaining of tissue samples.

Main Results:

  • Preputial MVD was significantly lower in the hypospadias group (33.95 ± 9.79) compared to controls (48.25 ± 10.08; p < 0.05).
  • No significant difference in preputial BF was observed between the hypospadias group (40.58 ± 16.16) and controls (33.09 ± 19.65; p > 0.05).

Conclusions:

  • No correlation was found between preputial MVD and BF in this study.
  • Reduced preputial MVD in distal hypospadias does not appear to influence preputial blood flow.
Abstract

Keywords:
Blood flowHypospadiasLaser Doppler flowmetryMicrovessel densityPrepuce

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