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Cyclic AMP and psoriasis.

K M Halprin, K Adachi, K Yoshikawa

    The Journal of Investigative Dermatology
    |July 1, 1975
    PubMed
    Summary
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    Mammalian epidermis contains adenyl cyclase, which responds to catecholamines and prostaglandins. Psoriatic lesions show reduced responsiveness, yet cyclic AMP levels remain normal, indicating complex regulation of skin cell growth.

    Area of Science:

    • Dermatology
    • Biochemistry
    • Cell Biology

    Background:

    • Mammalian epidermis possesses an adenyl cyclase system.
    • This system is activated by catecholamines and prostaglandins.
    • These activators bind to distinct receptor sites.

    Purpose of the Study:

    • To review evidence for adenyl cyclase in mammalian epidermis.
    • To investigate the response of psoriatic lesions to adenyl cyclase stimulators.
    • To compare cyclic AMP levels in psoriatic and normal epidermis.

    Main Methods:

    • Review of existing scientific evidence.
    • Analysis of adenyl cyclase activity in psoriatic lesions.
    • Measurement of cyclic AMP concentrations in skin samples.

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    Main Results:

    • Adenyl cyclase is present in all mammalian epidermis.
    • Psoriatic lesions exhibit a diminished response to stimulators, particularly catecholamines.
    • Epidermal cyclic AMP levels in psoriatic lesions are comparable to noninvolved skin.

    Conclusions:

    • The regulation of cyclic AMP in psoriatic epidermis is complex.
    • Reduced responsiveness to external stimulators does not equate to lower cyclic AMP levels.
    • The precise mechanisms by which cyclic nucleotides control skin cell proliferation and differentiation require further elucidation.