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Related Concept Videos

Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Sex Linked Disorders01:43

Sex Linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Community Based Intervention01:30

Community Based Intervention

Community-based interventions in mental health represent a paradigm shift from institution-centered care to treatments embedded within the fabric of local communities. By prioritizing inclusion and leveraging existing societal structures, this approach fosters a supportive environment conducive to addressing mental health challenges while promoting individual dignity and agency.
Foundations of Community Mental Health Programs
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Relationship with Other Adult Family Members and Siblings01:29

Relationship with Other Adult Family Members and Siblings

Other adult family members and siblings play a crucial role in shaping children’s social and emotional development. While parents or primary caregivers are often the central figures in early attachment and socialization, other adults in a child’s life, such as grandparents, aunts, and uncles, can significantly influence developmental outcomes. These influences depend on each adult’s personality and may help compensate when a primary caregiver is emotionally distant or inconsistent. For...
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Erikson's Theory on Socioemotional Development during Adolescence

Erik Erikson's fifth stage of psychosocial development, "identity versus role confusion," is crucial during adolescence (ages 12 to 18). In this stage, adolescents face the developmental task of forging a distinct personal identity, a process influenced by social, psychological, and biological changes typical of this period. Adolescents naturally explore different roles, behaviors, and ideologies as they navigate complex questions of self-concept, asking, "Who am I?" and "What is my place in...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:

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Related Experiment Video

Updated: May 9, 2026

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
09:19

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

Linking HSCs to their youth.

Eric M Pietras, Emmanuelle Passegué

    Nature Cell Biology
    |August 3, 2013
    PubMed
    Summary

    Fetal hematopoietic stem cells (HSCs) possess high self-renewal capacity due to the Lin28b/let-7/Hmga2 pathway. This mechanism can be harnessed to enhance the self-renewal of adult HSCs.

    Area of Science:

    • Hematology
    • Developmental Biology
    • Stem Cell Biology

    Background:

    • Fetal hematopoietic stem cells (HSCs) are responsible for establishing the entire blood system during development.
    • Adult HSCs exhibit lower self-renewal potential compared to their fetal counterparts.
    • The Lin28b protein plays a crucial role in maintaining high self-renewal in fetal HSCs.

    Discussion:

    • Lin28b negatively regulates the microRNA let-7.
    • This regulation leads to elevated levels of Hmga2, a key factor for self-renewal.
    • This molecular circuit is essential for the extensive regenerative capacity of fetal HSCs.

    Key Insights:

    • The Lin28b/let-7/Hmga2 pathway confers superior self-renewal potential to fetal HSCs.
    • Experimental modulation of this pathway is feasible.

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    High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
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    Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
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    Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

    Published on: July 24, 2019

  • Targeting this circuit offers a strategy to improve adult HSC function.

    • Outlook:

    • Potential therapeutic applications for regenerative medicine and treating blood disorders.
    • Further research into precise modulation techniques for clinical translation.
    • Understanding the long-term effects of manipulating this pathway in adult HSCs.