Transmitting senescence to the cell neighbourhood

Matthew Hoare1, Masashi Narita

  • 1Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK.

Nature Cell Biology
|August 3, 2013
PubMed
Summary

Cellular senescence, a tumor suppressor, can promote cancer via its secretory phenotype (SASP). New findings reveal SASP regulation by inflammasomes, suggesting senescence also acts as an immunity-linked tumor suppressor.

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