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Detection of beta-nerve growth factor mRNA in the human fetal brain
A Pizzuti1, G Borsani, A Falini
1Dino Ferrari Center, Institute of Neurology, University of Milan Medical School, Italy.
Brain Research
|June 4, 1990
Abstract:
Nerve growth factor (NGF) is a trophic molecule recently demonstrated to interact with different structures in the central nervous system. The expression of the beta-NGF mRNA from human fetal cortices at the 15-16th week of gestational age has been demonstrated and quantitated by polymerase chain reaction amplification of the specific cDNA. beta-NGF mRNA expression in the human brain coincides with the period of active differentiation and synaptogenesis, suggesting that the trophic agent plays a role in the cerebral development.