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Fabrication of Ultra-thin Color Films with Highly Absorbing Media Using Oblique Angle Deposition
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"OSMO-UT-DSAEK" using THIN-C medium.

F Bucher1, S Roters, A Mellein

  • 1Department of Ophthalmology, University of Cologne, Kerpenerstraße 62, 50924, Cologne, Germany, franziska.bucher@uk-koeln.de.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|August 3, 2013
PubMed
Summary
This summary is machine-generated.

Preconditioning corneas with THIN-C medium improved stromal interface quality for ultra-thin Descemet stripping automated endothelial keratoplasty (UT-DSAEK). However, this method did not enhance microkeratome cut precision for deeper, more reliable corneal transplants.

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Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Tissue Engineering

Background:

  • Ultra-thin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) relies on stromal interface quality and thickness for optimal visual outcomes.
  • Investigating methods to enhance graft preparation is crucial for improving UT-DSAEK success rates.

Purpose of the Study:

  • To evaluate the impact of additional osmotic deswelling using THIN-C medium prior to UT-DSAEK.
  • To determine if this preconditioning improves the stromal cut surface quality and microkeratome precision.

Main Methods:

  • Human donor corneas were divided into two groups: standard deswelling and additional osmotic deswelling with THIN-C medium.
  • Corneas underwent a double-path microkeratome cut in an artificial anterior chamber system.
  • Corneal thickness was measured using ultrasound biomicroscopy and histology, with histological grading of the cut surface.

Main Results:

  • Preconditioning with THIN-C medium significantly enhanced stromal interface smoothness (Pearson P = 0.019).
  • No significant correlation was found between ultrasound biomicroscopy and histological measurements of corneal thickness.
  • Microkeratome setting did not correlate significantly with the actual lenticule thickness in histological analysis.

Conclusions:

  • Osmotic preconditioning with THIN-C medium improves the stromal interface quality for UT-DSAEK.
  • This technique does not significantly enhance the precision of the microkeratome cut for graft preparation.