Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of the Heavy Neck in the Ethnic Patient.

Facial plastic surgery : FPS·2026
Same author

Asprosin infusion modulates central circuits to rescue selective serotonin reuptake inhibitor-induced male dysfunction.

Reproduction (Cambridge, England)·2026
Same author

ACMG-Recommended Actionable Secondary Findings from 1600 Clinical Exomes in the South Marmara Region in Turkiye.

International journal of molecular sciences·2026
Same author

Oscillatory dynamics in the adaptive exponential integrate-and-fire model.

Chaos (Woodbury, N.Y.)·2025
Same author

Apelin Regulates PVN Dopaminergic Activity and Limits Weight Gain in Mice: An Effect Attenuated by High-Fat Diet.

Molecular neurobiology·2025
Same author

Histological, Immunohistochemical, and Biochemical Evaluation of the Effect of Berberine on Ovarian Hyperstimulation Syndrome in Rats.

The journal of obstetrics and gynaecology research·2025

Related Experiment Video

Updated: May 9, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Injectable tissue-engineered cartilage using commercially available fibrin glue.

Ozcan Cakmak1, Seda T Babakurban, Hatice G Akkuzu

  • 1Acibadem University Faculty of Medicine-Otolaryngology Department, Ankara, Turkey.

The Laryngoscope
|August 3, 2013
PubMed
Summary

Injectable cartilage engineering using fibrin glue showed variable neocartilage formation. Optimizing fibrin glue concentration, cartilage source, or chondrocyte concentration did not significantly impact results in rabbit models.

Keywords:
Issue engineeringcartilagefibrin glueimmunocompromised

More Related Videos

Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization
12:13

Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization

Published on: October 28, 2013

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
06:15

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

Published on: June 14, 2015

Related Experiment Videos

Last Updated: May 9, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization
12:13

Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization

Published on: October 28, 2013

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
06:15

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

Published on: June 14, 2015

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Tissue Engineering

Background:

  • Injectable biomaterials are crucial for minimally invasive tissue regeneration.
  • Fibrin sealants offer potential as scaffolds for cartilage tissue engineering.
  • Optimizing injectable constructs requires understanding the influence of key components.

Purpose of the Study:

  • To develop injectable tissue-engineered cartilage using a commercial fibrin sealant.
  • To evaluate the impact of fibrin glue concentration, cartilage source, and chondrocyte density on neocartilage formation.
  • To assess the feasibility of using fibrin sealant as a carrier for chondrocytes in cartilage regeneration.

Main Methods:

  • New Zealand white rabbits (n=28) received injections of cultured chondrocytes within fibrin glue.
  • Variations in fibrin glue composition, cartilage source, and chondrocyte concentration were tested.
  • Tissue formation was analyzed macroscopically and histologically after 8 weeks.

Main Results:

  • Neocartilage formation (immature and mature) was observed in 36.36% of injection sites.
  • The volume of formed cartilage averaged 0.1 cc.
  • Inflammatory and foreign body reactions were noted around the engineered cartilage.
  • No significant differences in neocartilage formation were found based on varying fibrin glue concentrations, cartilage sources, or chondrocyte densities.

Conclusions:

  • Commercial fibrin sealant can support neocartilage formation in vivo.
  • The tested variations in fibrin glue components, cartilage source, and chondrocyte concentration did not significantly alter neocartilage formation outcomes.
  • Further research is needed to optimize injectable cartilage tissue engineering strategies.