Related Experiment Video
Updated: May 9, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Synthesis of sydnone substituted Biginelli derivatives as hyaluronidase inhibitors
Tegginamath Gireesh1, Ravindra R Kamble, Pramod P Kattimani
1Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad, India.
Abstract:
A novel series of Biginelli 2-3 (a and b) and Biginelli-like compounds 4-7 (a and b) were synthesized from 3-aryl-4-formylsydnone 1 (a and b). Since the crystal structure of hyaluronidase was unavailable, the human hyaluronidase protein structure was used as template and homology modeling was performed, validated by Ramachandran plots and subjected to docking studies along with in vitro anti-inflammatory activity assessment against hyaluronidase. Compounds 2-3 (a and b) exhibited potent enzyme inhibition.
More Related Videos
Related Concept Videos
Aldehydes and Ketones with HCN: Cyanohydrin Formation Overview
Alkylation of β-Diester Enolates: Malonic Ester Synthesis
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
Diazonium Group Substitution: –OH and –H
Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction

