Related Experiment Video
Updated: May 9, 2026

Quantifying Fitness Costs in Transgenic Aedes aegypti Mosquitoes
Published on: September 15, 2023
A single sex-linked dominant gene does not fully explain the codling moth's resistance to granulovirus
Marie Berling1, Benoît Sauphanor, Antoine Bonhomme
1EMA, Centre LGEI, Ales, France.
Background:
In 2004, resistance to a commercial formulation of the Cydia pomonella granulovirus (CpGV) was identified in a field population of Cydia pomonella from an organic orchard in southern France. The genetic inheritance of this resistance was analysed in the resistant laboratory strain RGV. This strain was obtained using successive crosses between the resistant field population and a susceptible laboratory strain, SV, with selection for CpGV resistance at each generation.
Results:
After eight generations of introgression of the resistant trait into SV, the RGV-8 strain exhibited 7000-fold higher resistance than SV. Mass-crossing experiments showed that resistance to CpGV is strongly dominant, sex dependent and under the control of a single major gene. However, the contribution of other genes is required to explain all of the data obtained in this study. These additional genes do not follow the laws of classical Mendelian transmission.
Conclusion:
Transmission of granulovirus resistance in the RGV-8 strain of C. pomonella cannot be fully explained by the effect of a locus located on the Z chromosome. The action of other factors needs to be considered.
Related Concept Videos
Dosage Compensation
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will have...
The Ratio of X Chromosome to Autosomes
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
X-linked Traits
X-linked Traits
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon has three reading...
X and Y Chromosomes
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...

