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Related Experiment Videos

Coexisting ankylosing spondylitis and Paget's disease.

I Olivieri1, R Semeria, G Gemignani

  • 1Institute of Medical Pathology 1, University of Pisa, Italy.

Clinical Rheumatology
|June 1, 1990
PubMed
Summary

This report details a rare case of coexisting ankylosing spondylitis (AS) and Paget's disease. Accurate diagnosis is crucial, as Paget's disease can mimic AS symptoms.

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Area of Science:

  • Rheumatology
  • Orthopedics
  • Genetics

Background:

  • Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the spine.
  • Paget's disease of bone is a condition characterized by abnormal bone remodeling.

Observation:

  • A 59-year-old male patient presented with HLA B27 negative ankylosing spondylitis.
  • The patient also had Paget's disease affecting the skull, pelvis, and femur.

Findings:

  • This case represents a rare coexistence of AS and Paget's disease.
  • Previous literature includes fifteen cases of this comorbidity.
  • Some reported cases highlight Paget's disease mimicking AS.

Implications:

  • Emphasizes the importance of careful diagnosis in patients with coexisting conditions.

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  • Highlights the potential for Paget's disease to present with symptoms similar to AS.
  • Underscores the need for clinicians to consider both diagnoses when symptoms overlap.