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Related Concept Videos

Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism.
Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism.
The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential.
Electrochemical Gradient and Channel Proteins: An Overview01:21

Electrochemical Gradient and Channel Proteins: An Overview

An electrochemical gradient is a fundamental concept in biology and chemistry. It regulates the movement of ions across cell membranes. This movement is influenced by two factors:
The electrical gradient: The electrical gradient across cell membranes refers to the difference in electric charge between the inside and outside of a cell.  This difference drives the movement of ions towards or away from the cells. For instance, if the inside of the cell is more negatively charged relative to the...
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...

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Related Experiment Video

Updated: May 9, 2026

Study of the Functions and Activities of Neuronal K-Cl Co-Transporter KCC2 Using Western Blotting
10:08

Study of the Functions and Activities of Neuronal K-Cl Co-Transporter KCC2 Using Western Blotting

Published on: December 9, 2022

TASK-2: a K2P K(+) channel with complex regulation and diverse physiological functions.

L Pablo Cid1, Hugo A Roa-Rojas, María I Niemeyer

  • 1Centro de Estudios Científicos Valdivia, Chile.

Frontiers in Physiology
|August 3, 2013
PubMed
Summary

The TASK-2 (K2P5.1) potassium channel is activated by pH changes and involved in kidney function, neuronal signaling, and cell volume regulation. Its roles in cartilage, neurons, and cancer cells suggest therapeutic potential.

Keywords:
K2P channelsTASK-2 channelbicarbonate reabsorptioncell volume regulationcentral chemoceptionchondrocytes

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Patch Clamp and Perfusion Techniques for Studying Ion Channels Expressed in Xenopus oocytes
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Patch Clamp and Perfusion Techniques for Studying Ion Channels Expressed in Xenopus oocytes

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Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors
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Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

Published on: February 10, 2014

Related Experiment Videos

Last Updated: May 9, 2026

Study of the Functions and Activities of Neuronal K-Cl Co-Transporter KCC2 Using Western Blotting
10:08

Study of the Functions and Activities of Neuronal K-Cl Co-Transporter KCC2 Using Western Blotting

Published on: December 9, 2022

Patch Clamp and Perfusion Techniques for Studying Ion Channels Expressed in Xenopus oocytes
10:19

Patch Clamp and Perfusion Techniques for Studying Ion Channels Expressed in Xenopus oocytes

Published on: January 10, 2011

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors
10:59

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

Published on: February 10, 2014

Area of Science:

  • Molecular Biology
  • Physiology
  • Cell Biology

Background:

  • TASK-2 (K2P5.1) is a two-pore domain potassium channel in the TALK subgroup.
  • It is activated by both extracellular and intracellular alkalinization.
  • pH-sensing mechanisms involve specific arginine and lysine residues affecting channel gates.

Purpose of the Study:

  • To elucidate the diverse physiological roles of the TASK-2 channel.
  • To investigate TASK-2's function in various cell types and tissues.
  • To explore TASK-2's potential as a therapeutic target.

Main Methods:

  • The abstract does not specify experimental methods but discusses proposed functions based on existing knowledge.
  • It implies a review or synthesis of current research on TASK-2.
  • Functional roles are inferred from expression patterns and known channel properties.

Main Results:

  • TASK-2 activation by alkalinization is linked to kidney bicarbonate reabsorption and central chemosensation.
  • It plays a role in apoptotic volume decrease and cell volume regulation in various cell types.
  • TASK-2 is expressed in chondrocytes, neurons, pancreas, and intestinal smooth muscle cells.

Conclusions:

  • TASK-2 is a versatile channel with significant roles in pH homeostasis, cell volume, and neuronal function.
  • Its presence in diverse tissues suggests broad physiological importance.
  • TASK-2's involvement in breast cancer proliferation highlights its potential as a therapeutic target.