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Updated: May 9, 2026
26:48
Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
Benign-onset acute disseminated encephalomyelitis: a report on two cases
Eylem Degirmenci1, Cagdas Erdogan, Attila Oguzhanoglu
1Pamukkale University, Faculty of Medicine, Neurology Department, Denizli, Turkey. eylemteke@yahoo.com
Ideggyogyaszati Szemle
|August 6, 2013
Summary
Acute disseminated encephalomyelitis (ADEM) presents with varied neurological symptoms. This report details two benign cases of ADEM, highlighting diverse clinical presentations.
Area of Science:
- Neuroscience
- Immunology
- Neurology
Background:
- Acute disseminated encephalomyelitis (ADEM) is an immune-mediated inflammatory demyelinating disease of the central nervous system.
- ADEM is characterized by a sudden onset of multifocal neurological deficits.
- Clinical presentations are heterogeneous, influenced by lesion location and severity.
Observation:
- The study reports two cases of ADEM with distinct initial symptoms.
- Despite varied presentations, both patients exhibited benign clinical outcomes.
- This highlights the broad spectrum of ADEM manifestations.
Findings:
- ADEM can manifest with meningoencephalitic features like confusion, seizures, and impaired consciousness.
- Multifocal neurological signs such as optic neuritis, cranial neuropathies, and sensorimotor deficits are common.
- The two presented cases, though different, resolved favorably, indicating a benign course.
Implications:
- Understanding the diverse clinical spectrum of ADEM is crucial for accurate diagnosis.
- Recognizing benign presentations can aid in appropriate patient management and prognosis.
- Further research into ADEM's varied etiologies and outcomes is warranted.
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