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Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
26:48

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

Benign-onset acute disseminated encephalomyelitis: a report on two cases

Eylem Degirmenci1, Cagdas Erdogan, Attila Oguzhanoglu

  • 1Pamukkale University, Faculty of Medicine, Neurology Department, Denizli, Turkey. eylemteke@yahoo.com

Ideggyogyaszati Szemle
|August 6, 2013
PubMed

Insights

Acute disseminated encephalomyelitis (ADEM) presents with varied neurological symptoms. This report details two benign cases of ADEM, highlighting diverse clinical presentations.

Area of Science:

  • Neuroscience
  • Immunology
  • Neurology

Background:

  • Acute disseminated encephalomyelitis (ADEM) is an immune-mediated inflammatory demyelinating disease of the central nervous system.
  • ADEM is characterized by a sudden onset of multifocal neurological deficits.
  • Clinical presentations are heterogeneous, influenced by lesion location and severity.

Observation:

  • The study reports two cases of ADEM with distinct initial symptoms.
  • Despite varied presentations, both patients exhibited benign clinical outcomes.
  • This highlights the broad spectrum of ADEM manifestations.

Findings:

  • ADEM can manifest with meningoencephalitic features like confusion, seizures, and impaired consciousness.
  • Multifocal neurological signs such as optic neuritis, cranial neuropathies, and sensorimotor deficits are common.
  • The two presented cases, though different, resolved favorably, indicating a benign course.

Implications:

  • Understanding the diverse clinical spectrum of ADEM is crucial for accurate diagnosis.
  • Recognizing benign presentations can aid in appropriate patient management and prognosis.
  • Further research into ADEM's varied etiologies and outcomes is warranted.

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