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Related Experiment Video

Updated: May 9, 2026

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation

Published on: July 23, 2012

Myeloid dendritic cells type 2 in allergic asthma.

B Dua¹, S Smith, T Kinoshita

¹Firestone Institute of Respiratory Health, Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.

|August 6, 2013

Summary

This summary is machine-generated.

Circulating myeloid dendritic cells type 2 (mDC2s) are lower in individuals with allergies and asthma. This suggests mDC2s may move from blood to airways in allergic disease.

Keywords:

BDCA-3 dendritic cells moderate/severe asthma myeloid dendritic cells type 2 (mDC2s)

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Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

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Published on: April 16, 2019

Area of Science:

Immunology
Allergy Research
Cell Biology

Background:

Myeloid dendritic cells type 2 (mDC2s) are a recently identified DC subtype.
mDC2s are found in circulation and lungs.
mDC2s are implicated in allergic asthma pathogenesis.

Purpose of the Study:

To quantify circulating mDC2s in healthy, atopic nonasthmatic, and asthmatic individuals.
To investigate the relationship between mDC2 levels and allergy/asthma severity.

Main Methods:

Flow cytometry was used to enumerate circulating mDC2s.
Subjects included healthy controls and individuals with varying degrees of atopy and asthma.

Main Results:

Circulating mDC2s were significantly lower in atopic and asthmatic subjects compared to healthy controls.
A trend of decreasing mDC2 levels was observed with increasing allergy and asthma severity.
Moderate/severe atopic asthmatics had significantly fewer mDC2s (430.78 ± 48.91/ml) than healthy controls (767.05 ± 101.64/ml).

Conclusions:

Lower circulating mDC2 counts are associated with atopy and asthma.
These findings suggest mDC2s may migrate from the blood to the airways in allergic diseases.