Interplay among subunit identity, subunit proportion, chain length, and stereochemistry in the activity profile of
Zvi Hayouka1, Saswata Chakraborty, Runhui Liu
1Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.
Abstract:
Fmoc-based solid-phase synthesis methodology was used to prepare peptide mixtures containing one type of hydrophobic residue and one type of cationic residue. Each mixture was random in terms of sequence but highly controlled in terms of length. Analysis of the antibacterial and hemolytic properties of these mixtures revealed that selective antibacterial activity can be achieved with heterochiral binary mixtures but not homochiral binary mixture, if the proper amino acid residues are used.
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