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Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Overview of Nitrogen Metabolism01:20

Overview of Nitrogen Metabolism

Nitrogen is a very important element for life because it is a major constituent of proteins and nucleic acids. It is a macronutrient, and in nature, it is recycled from organic compounds and stored in the form of  ammonia, ammonium ions, nitrate, nitrite, or  nitrogen gas by many metabolic processes. Many of these metabolic processes are carried out only by prokaryotes.
The largest pool of nitrogen available in the terrestrial ecosystem is gaseous nitrogen (N2) from the air, but this nitrogen...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Troponins
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Blood Studies I: ABG and VBG01:26

Blood Studies I: ABG and VBG

Blood studies are critical in the medical field, enabling healthcare professionals to assess a patient's health status accurately. This page will focus on two significant blood studies: Arterial Blood Gas (ABG) and Venous Blood Gas (VBG).
Arterial Blood Gas (ABG)
Arterial Blood Gas (ABG) studies are crucial for assessing the lungs' ability to supply oxygen and remove carbon dioxide, reflecting the patient's ventilation status. They also help understand the kidneys' capacity to reabsorb or...
The Nitrogen Cycle01:49

The Nitrogen Cycle

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Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure to...

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Related Experiment Video

Updated: May 9, 2026

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management
08:01

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

Nitrogen biobank for cardiovascular research.

Antonella Mercuri1, Stefano Turchi, Andrea Borghini

  • 1U.O. Biobank, CNR, Institute of Clinical Physiology, Pisa, Italy.

Current Cardiology Reviews
|August 6, 2013
PubMed
Summary

Biobanks are vital for "-Omics" research, offering high-quality samples for disease study. This paper details preanalytical best practices and a secure liquid nitrogen storage system for optimal sample preservation and research impact.

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Area of Science:

  • Biomedical research
  • Biobanking
  • Cardiovascular disease research

Background:

  • Biobanks are crucial for -Omics research, providing well-annotated samples for disease mechanism studies.
  • Professionalization of biobanks enhances sample preservation and storage, increasing scientific impact.
  • High-quality sample collections are essential for understanding cardiovascular diseases, including congenital heart disease and cardiomyopathies.

Purpose of the Study:

  • To focus on preanalytical issues in biological sample collection for research.
  • To describe the implementation of a high-security liquid nitrogen storage system (-196°C).
  • To ensure the quality and suitability of stored biological samples for research.

Main Methods:

  • Focus on preanalytical issues: informed consent, sample type, collection time, temperature, and processing.
  • Overview of a newly designed and implemented high-security liquid nitrogen storage system.
  • Implementation of reliable preservation technologies and quality control measures.

Main Results:

  • Detailed examination of critical preanalytical factors influencing sample quality.
  • Successful implementation of a secure liquid nitrogen storage system at -196°C.
  • Established robust quality control for temperature, environment, and traceability with backup systems.

Conclusions:

  • Adherence to preanalytical best practices is essential for high-quality biobanking.
  • The implemented liquid nitrogen system ensures maximum security and sample integrity.
  • Professionalized biobanks with advanced storage solutions significantly advance cardiovascular disease research and personalized medicine.