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Updated: May 9, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Applying antithrombotic therapies to improve outcomes in patients with atrial fibrillation
Chris Cannon1, Michael D Ezekowitz, Christopher Granger
1Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Insights
Atrial fibrillation significantly increases stroke risk, necessitating better patient identification and management. This educational webcast explores antithrombotic therapies and physician decision-making for anticoagulation in atrial fibrillation patients.
Area of Science:
- Cardiology
- Neurology
- Pharmacology
Background:
- Atrial fibrillation is a common arrhythmia affecting over 2.66 million Americans, significantly increasing stroke and mortality risk.
- Approximately 15-25% of ischemic strokes in the US are linked to atrial fibrillation, highlighting a critical public health concern.
- Managing atrial fibrillation involves addressing challenges in risk identification, guideline adherence, comorbidity control, and patient compliance.
Purpose of the Study:
- To discuss the current landscape of antithrombotic therapies for atrial fibrillation.
- To review new anticoagulant options and factors influencing their clinical use.
- To provide insights into clinical decision-making and expert lessons for managing anticoagulation in atrial fibrillation.
Main Methods:
- This content is based on an educational webcast format.
- Expert faculty discuss clinical decision-making and lessons learned.
- The webcast reviews current antithrombotic therapies and new anticoagulants.
Main Results:
- Atrial fibrillation poses a substantial risk for thromboembolic events, including stroke.
- Effective management requires addressing multiple challenges, from patient identification to treatment adherence.
- Physician factors significantly influence the utilization of anticoagulation in atrial fibrillation.
Conclusions:
- Optimizing anticoagulation in atrial fibrillation is crucial for reducing morbidity and mortality.
- Understanding the complexities of antithrombotic therapy and physician decision-making is essential.
- Continuous education and adherence to guidelines are vital for improving patient outcomes in atrial fibrillation.
Abstract:
Approximately 15% to 25% or 75,000 ischemic strokes are attributed to atrial fibrillation annually within the United States. Atrial fibrillation is the most frequently diagnosed cardiac arrhythmia and affects more than 2.66 million Americans. Moreover, atrial fibrillation is associated with a 1.5 to 1.9-fold higher risk of death due to its strong correlation with thromboembolic events. Because of the attributed increased morbidity and mortality, challenges that concern identification of patients at risk for thromboembolic events from atrial fibrillation must be addressed. These challenges include compliance to performance measures, adherence to guidelines, adequate prevention and early control of co-morbidities that affect the progression of atrial fibrillation and associated risks, early initiation of treatment, and successful evaluation of associated risks of bleeding, primary or recurrent stroke, and patient awareness and compliance. This multimedia educational webcast will discuss the state of affairs with respect to antithrombotic therapies and new anticoagulants. The webcast will also review factors influencing physician use of anticoagulation in atrial fibrillation. Clinical decision making and lessons learned from the expert faculty is also included.
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