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Related Experiment Video

Updated: May 9, 2026

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling

Published on: December 18, 2017

On your (methyl) mark, get TET1, go!

Shradha Mukherjee¹, Jenny Hsieh

¹Department of Molecular Biology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

|August 6, 2013

Summary

Tet1 protein regulates adult neurogenesis in the hippocampus by controlling progenitor cell growth. Tet1 deficiency impairs learning and memory functions, highlighting its crucial role in the adult brain.

Area of Science:

Epigenetics and developmental biology
Neuroscience and stem cell research

Background:

Tet proteins and DNA demethylation are crucial for embryonic stem cell regulation.
The specific roles of Tet proteins in adult tissue stem cells and neurogenesis are not well understood.

Purpose of the Study:

To investigate the function of Tet1 in adult hippocampal neurogenesis.
To determine the impact of Tet1 deficiency on learning and memory.

Main Methods:

Utilized mouse models to study the role of Tet1 in the adult hippocampus.
Assessed progenitor cell proliferation and neurogenesis in Tet1-deficient mice.
Evaluated learning and memory capabilities through behavioral tests.

Main Results:

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Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Published on: November 22, 2014

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Last Updated: May 9, 2026

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling

Published on: December 18, 2017

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase

Published on: October 15, 2018

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Published on: November 22, 2014

Tet1 was found to regulate adult hippocampal neurogenesis by controlling progenitor cell proliferation.

Tet1 deficiency led to significant defects in learning and memory.

Conclusions:

Tet1 plays a critical role in adult hippocampal neurogenesis and cognitive functions.
These findings suggest Tet1 as a potential target for cognitive disorders.