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Related Concept Videos

Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...

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Related Experiment Video

Updated: May 9, 2026

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

Sutureless mitral valve replacement: initial steps toward a percutaneous procedure.

Matthew J Gillespie1, Masahito Minakawa, Masato Morita

  • 1Division of Cardiology, The Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-5156, USA.

The Annals of Thoracic Surgery
|August 6, 2013
PubMed
Summary
This summary is machine-generated.

Sutureless mitral valve replacement (SMV) shows promise for heart valve therapy. This novel device successfully anchored and sealed in sheep, demonstrating feasibility for future clinical use.

Keywords:
35

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Related Experiment Videos

Last Updated: May 9, 2026

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Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
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Published on: March 26, 2018

Area of Science:

  • Cardiovascular Medicine
  • Biomedical Engineering
  • Surgical Innovation

Background:

  • Transcatheter mitral valve replacement is a significant advancement in cardiac therapy.
  • Current methods require specialized anchoring and sealing technologies.
  • A novel sutureless mitral valve (SMV) device aims to address these challenges.

Purpose of the Study:

  • To evaluate the feasibility of a novel sutureless mitral valve (SMV) device.
  • To assess the device's ability to anchor and seal in the mitral position without sutures.

Main Methods:

  • The SMV device features a self-expanding nitinol framework and a pericardial leaflet valve.
  • Surgical implantation was performed in ten sheep.
  • Postoperative assessment included cardiac catheterization, echocardiography, angiography, and necroscopy.

Main Results:

  • Successful SMV device implantation was achieved in all ten sheep.
  • Echocardiography and angiography showed excellent left ventricular function, no significant perivalvular leak, stenosis, or outflow tract obstruction.
  • Necropsy confirmed secure anchoring of the SMV devices.

Conclusions:

  • This study demonstrates the feasibility of sutureless mitral valve replacement.
  • The novel SMV device shows short-term success in a preclinical model.
  • Further research is warranted for clinical application.