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Updated: May 9, 2026
07:07
Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
Published on: January 12, 2017
Dentin adhesion and MMPs: a comprehensive review
Jorge Perdigão1, Alessandra Reis, Alessandro D Loguercio
1Department of Restorative Sciences, University of Minnesota, Minneapolis, MN 55455, USA. perdi001@umn.edu
Summary
This review explores how water damages resin-dentin bonds over time. It discusses preventing degradation by addressing collagen breakdown and protease activity in dental adhesives.
Area of Science:
- Biomaterials Science
- Dental Materials Science
- Polymer Degradation
Background:
- Resin-bonded interfaces are crucial for dental restorations.
- Dentin adhesives' hydrophilic and acidic nature leads to water sorption.
- Water sorption degrades the hybrid layer, reducing bond strength over time.
Purpose of the Study:
- To review aging mechanisms in resin-bonded interfaces.
- To explore strategies for preventing and counteracting degradation.
- To discuss methods for increasing resin-dentin bond durability.
Main Methods:
- Review of current scientific literature on resin-dentin bonding.
- Analysis of degradation pathways of the hybrid layer.
- Examination of endogenous protease activity and inhibition strategies.
Main Results:
- Hydrophilic dentin adhesives cause water sorption in hybrid layers.
- Degraded polymers expose collagen fibers to fatigue and enzymatic breakdown.
- Matrix metalloproteinases and cysteine cathepsins degrade type I collagen.
Conclusions:
- Understanding hybrid layer degradation is key to improving bond durability.
- Inhibiting endogenous proteases offers a promising approach to enhance bond longevity.
- Further research is needed to develop stable resin-dentin interfaces.
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