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Updated: May 9, 2026

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
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PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

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Radiotherapy in craniopharyngiomas.

A Iannalfi1, I Fragkandrea, J Brock

  • 1National Center for Oncological Hadrontherapy, Pavia, Italy.

Clinical Oncology (Royal College of Radiologists (Great Britain))
|August 6, 2013
PubMed
Summary

Optimal craniopharyngioma management involves conservative surgery followed by radiotherapy. This approach offers excellent local control and reduced complications compared to aggressive surgery, with recommended doses of 50-54 Gy.

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Analysis of tumour microstructure estimation from conventional diffusion MRI and application to skull-base chordoma<sup></sup>.

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Area of Science:

  • Neuro-oncology
  • Radiation Oncology
  • Neurosurgery

Background:

  • Craniopharyngioma management is debated, with aggressive surgery risking morbidity and recurrence.
  • A conservative surgical approach combined with radiotherapy is gaining traction due to improved outcomes.

Purpose of the Study:

  • To review and analyze outcomes and toxicity of radiotherapy for craniopharyngioma.
  • To compare radiotherapy-based strategies with radical surgery.

Main Methods:

  • Literature review of 43 studies (1990-2012) involving 1716 patients treated with craniopharyngioma irradiation.
  • Analysis of outcomes (local control, survival) and toxicity based on radiotherapy timing, volume, and dose.
  • Comparison with radical surgery outcomes.
Keywords:
Craniopharyngiomaintracavitary irradiationproton beam therapyradiosurgeryradiotherapystereotactic radiotherapy

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Main Results:

  • Limited surgery with postoperative radiotherapy showed 10-year local control rates of 77-100% and 20-year overall survival of 66-92%.
  • Radiotherapy at initial diagnosis or progression yielded comparable survival rates.
  • Combined limited surgery and irradiation demonstrated potentially lower long-term toxicity than radical surgery.

Conclusions:

  • A total dose of 50-54 Gy with conventional fractionation is recommended for long-term craniopharyngioma control while minimizing adverse effects.
  • Multidisciplinary team care in specialized centers is crucial.
  • Prospective trials are needed to establish a definitive, risk-based management strategy.