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Related Concept Videos

Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
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Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...

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Assessing Specificity of Anticancer Drugs In Vitro
09:39

Assessing Specificity of Anticancer Drugs In Vitro

Published on: March 23, 2016

Adherence enhancing interventions for oral anticancer agents: a systematic review.

Tim Mathes1, Sunya-Lee Antoine, Dawid Pieper

  • 1Institute for Research in Operative Medicine, Faculty of Health - School of Medicine, Witten/Herdecke University, Ostmerheimer Str. 200, Building 33, D-51109 Cologne, Germany.

Cancer Treatment Reviews
|August 6, 2013
PubMed
Summary

Adherence interventions for oral anticancer agents show limited effectiveness, though some show promise. Careful patient selection is key to avoid ceiling effects, but more high-quality studies are needed.

Keywords:
Medication adherenceNeoplasmsOncologyOral anticancer agentsOral chemotherapyPatient compliance

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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
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Published on: February 6, 2015

Area of Science:

  • Oncology
  • Pharmacology
  • Health Services Research

Background:

  • Oral anticancer agents are increasingly used, making patient adherence critical for treatment success.
  • Despite its importance, non-adherence to oral anticancer therapy is a common challenge.
  • This highlights the need to investigate strategies to improve patient adherence.

Purpose of the Study:

  • To systematically evaluate the effectiveness of interventions designed to improve adherence in patients receiving oral anticancer agents.
  • To synthesize evidence from existing studies on adherence interventions in this patient population.

Main Methods:

  • A systematic literature search was conducted in Medline and Embase databases.
  • Studies were screened for eligibility based on predefined criteria, with quality assessment performed by two independent reviewers.
  • Data on study design, patient characteristics, interventions, and outcomes were extracted and verified.

Main Results:

  • Six controlled studies were included, with only one being randomized and overall study quality rated as moderate to low.
  • One study demonstrated statistically significant improvement with the adherence intervention, while two others showed a positive trend.
  • Results were inconsistent across studies, with one showing no difference and another favoring the control group, underscoring variability in effectiveness.

Conclusions:

  • Current adherence interventions for oral anticancer agents have limited effectiveness, but some approaches show potential.
  • Considering baseline adherence is crucial to prevent ceiling effects and accurately assess intervention efficacy.
  • The evidence base is constrained by a scarcity of studies and inconsistent findings, necessitating further high-quality research.