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Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
Published on: August 4, 2018
Changes in blood coagulation induced by exercise training in young athletic horses
A Assenza1, F Tosto, S Casella
1Dipartimento di Scienze Sperimentali e Biotecnologie Applicate, Laboratorio di Fisiologia Comparata dell'Esercizio Fisico, Facoltà di Medicina Veterinaria, Università degli Studi di Messina, Polo Universitario Annunziata, 98168 Messina, Italy.
Training young athletic horses impacts their blood clotting times and platelet counts. These changes in Prothrombin Time (PT), Activated Partial Prothrombin Time (APTT), Fibrinogen (Fbg), and Platelets (Plt) are normal physiological responses to exercise.
Area of Science:
- Equine Sports Medicine
- Exercise Physiology
- Hemostasis and Thrombosis
Background:
- Athletic training in horses can influence physiological parameters.
- Understanding hemostatic system adaptations is crucial for equine athletes.
Purpose of the Study:
- To evaluate changes in coagulation and platelet parameters in young athletic horses undergoing a training program.
- To assess the relationship between training progression and hemostatic function.
Main Methods:
- 20 young athletic horses were monitored over an 80-day training period.
- Standardized exercise tests (SET) were conducted monthly.
- Blood samples were analyzed for Prothrombin Time (PT), Activated Partial Prothrombin Time (APTT), Fibrinogen (Fbg), and Platelet number (Plt).
- Athletic performance was assessed using V4 (lactate-based speed).
Main Results:
- Significant variations (P < 0.001) were observed in V4, PT, and Plt throughout training.
- Significant variations (P < 0.01) were also noted in APTT and Fbg.
- All measured hemostatic parameters demonstrated significant changes during the training program.
Conclusions:
- Training-induced modifications in the clotting mechanism are a normal physiological response in horses.
- The hemostatic system adapts to the demands of training exercise.
- These findings provide insights into the physiological adaptations of equine athletes.
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