Related Experiment Video
Updated: May 9, 2026
08:30
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
Published on: March 12, 2016
A curious case of glaucoma?
Elizabeth L Pinney1, Henry A Ferreyra1, Larry Frohman2
1Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, La Jolla, California.
Survey of Ophthalmology
|August 6, 2013
Summary
Autoimmune retinopathy, a rare condition, can mimic glaucoma. Early detection through antibody testing and electroretinography is crucial for accurate diagnosis and management of vision loss.
Area of Science:
- Ophthalmology
- Immunology
- Neuroscience
Background:
- Primary open-angle glaucoma (POAG) is a common optic neuropathy.
- Visual field deficits disproportionate to optic nerve appearance warrant further investigation.
Observation:
- An 84-year-old woman presented with visual field loss not explained by her POAG diagnosis.
- She exhibited progressive visual field defects and impaired color vision.
Findings:
- Electroretinography showed abnormal scotopic and photopic responses.
- Serum analysis revealed anti-retinal antibodies.
- Malignancy screening was negative, ruling out paraneoplastic syndromes.
Implications:
- This case highlights non-paraneoplastic autoimmune retinopathy as a differential diagnosis in glaucoma suspects with atypical presentations.
- Prompt identification of autoimmune retinopathy is vital for appropriate treatment and vision preservation.
- Multimodal diagnostic approaches, including imaging and immunological assays, are essential for complex ophthalmic cases.
Related Concept Videos
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:22Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
01:16Focusing of Light in the Eye
Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...