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Updated: Jan 23, 2026

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
Published on: December 18, 2017
Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes
Geeta J Narlikar1, Ramasubramanian Sundaramoorthy, Tom Owen-Hughes
1Biochemistry and Biophysics, Genentech Hall 600, 16th Street, University of California, San Francisco, San Francisco, CA 94158, USA. geeta.narlikar@ucsf.edu
Abstract:
Chromatin provides both a means to accommodate a large amount of genetic material in a small space and a means to package the same genetic material in different chromatin states. Transitions between chromatin states are enabled by chromatin-remodeling ATPases, which catalyze a diverse range of structural transformations. Biochemical evidence over the last two decades suggests that chromatin-remodeling activities may have emerged by adaptation of ancient DNA translocases to respond to specific features of chromatin. Here, we discuss such evidence and also relate mechanistic insights to our understanding of how chromatin-remodeling enzymes enable different in vivo processes.
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