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Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
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Subsequent T...
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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Related Experiment Video

Updated: May 9, 2026

Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay
09:57

Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay

Published on: August 6, 2020

Transplacentally transferred functional antibodies against Plasmodium falciparum decrease with age.

Patrick T Wilson1, Indu Malhotra, Peter Mungai

  • 1Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, USA.

Acta Tropica
|August 6, 2013
PubMed
Summary
This summary is machine-generated.

Functional antibodies against malaria are transferred from mothers to newborns, providing passive immunity. These protective antibodies wane over the first year of infancy, potentially impacting protection against Plasmodium falciparum.

Keywords:
Functional antibodiesGrowth inhibition assayMalariaPlasmodium falciparum

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Maternal-Fetal Health

Background:

  • Transplacental antibody transfer is believed to confer passive immunity to infants against malaria.
  • The presence and longevity of functional anti-Plasmodium falciparum (Pf) antibodies in newborns remain underexplored.

Purpose of the Study:

  • To quantify functional anti-malaria antibodies at birth and track their levels throughout the first year of life.
  • To assess the transplacental transfer of functional antibodies and their persistence in infants.

Main Methods:

  • Utilized growth inhibition assays (GIA) to measure functional antibodies against Plasmodium falciparum.
  • Analyzed cord blood samples from newborns and infant samples at six and 12 months.
  • Tested antibody function against three laboratory Pf strains (D10, W2mef, 3D7) and one field isolate (Msambweni 2006).

Main Results:

  • Significant differences in median GIA levels were observed across different Pf strains at birth.
  • GIA levels demonstrated a decline in infants from birth to six months of age.
  • Functional antibodies are indeed transferred to the fetus and decrease in concentration over time.

Conclusions:

  • Functional anti-Plasmodium falciparum antibodies are transferred from immune mothers to their fetuses.
  • The levels of these protective antibodies wane during infancy, suggesting a temporary protective window.
  • These functional antibodies likely contribute partially to infant protection against clinical malaria disease.