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Related Experiment Video

Updated: May 9, 2026

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds
08:02

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

Published on: January 7, 2019

Anionic carbohydrate-containing chitosan scaffolds for bone regeneration.

Hyejin Park1, Bogyu Choi, John Nguyen

  • 1Division of Advanced Prosthodontics, University of California, Los Angeles, CA 90095, United States.

Carbohydrate Polymers
|August 6, 2013
PubMed
Summary

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Composite chitosan scaffolds with apatite coatings show promise for bone tissue engineering. These enhanced scaffolds improve bone marrow stromal cell (BMSC) delivery and osteogenic differentiation, offering a potential solution for bone regeneration.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Biomedical Engineering

Background:

  • Naturally derived polysaccharide scaffolds are crucial for bone tissue engineering due to biocompatibility.
  • Chitosan (CH) scaffolds are widely studied but can be improved for enhanced cell interaction and mechanical properties.

Purpose of the Study:

  • To develop and evaluate composite chitosan scaffolds incorporating chondroitin 4-sulfate (CS) or alginate (AG) with a biomimetic apatite layer.
  • To assess the scaffolds' capacity for delivering progenitor cells (bone marrow stromal cells, BMSC) and model proteins (histone, BSA).
  • To investigate the effect of apatite coating on scaffold properties and BMSC osteogenic differentiation.

Main Methods:

  • Fabrication of composite chitosan scaffolds with CS or AG.
Keywords:
AlginateBiomimetic apatiteBone regenerationChitosanChondroitin sulfateScaffold

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Last Updated: May 9, 2026

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Published on: January 7, 2019

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
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  • Coating scaffolds with a biomimetic apatite layer.
  • In vitro assessment of protein release kinetics (histone, BSA).
  • Evaluation of BMSC behavior (spreading, proliferation, osteogenic differentiation) using assays and microscopy.

    • Main Results:

    • Incorporation of CS or AG increased scaffold compressive modulus and apatite formation.
    • CS/AG addition reduced initial burst release of positively charged histone via electrostatic interactions.
    • Apatite coating significantly reduced burst release of both BSA and histone.
    • Apatite-coated scaffolds enhanced BMSC spreading, proliferation, and osteogenic differentiation.

    Conclusions:

    • Apatite-coated chitosan/chondroitin 4-sulfate composite scaffolds demonstrate significant potential for bone tissue engineering.
    • The biomimetic apatite layer and composite structure enhance cell response and protein delivery control.
    • These scaffolds represent a promising osteogenic system for bone regeneration applications.