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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
The Colloidal State01:29

The Colloidal State

The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called the...
Solubility03:00

Solubility

Solution, Solubility, and Solubility Equilibrium
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
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Bioavailability Enhancement: Drug Solubility Enhancement

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Updated: May 9, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Dextran-based cyclodextrin polymers: their solubilizing effect and self-association.

Zoltán Fülöp1, Thorbjørn T Nielsen, Kim L Larsen

  • 1Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, 107 Reykjavík, Iceland. zof1@hi.is

Carbohydrate Polymers
|August 6, 2013
PubMed
Summary
This summary is machine-generated.

New dextran-based cyclodextrin polymers show potential as pharmaceutical excipients, but their effectiveness decreases with higher molecular weight. Ether linkages offer more favorable properties than ester linkages for drug solubilization.

Keywords:
BEBSCDComplexationCyclodextrin polymersHCPermeationSESelf-associationbinding efficiencybinding sitescyclodextrinhydrocortisonesolubilization efficiency

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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
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Published on: August 2, 2012

Area of Science:

  • Pharmaceutical Science
  • Polymer Chemistry

Background:

  • Cyclodextrins (CDs) and their derivatives are crucial pharmaceutical excipients for enhancing drug solubility and stability.
  • Ongoing research focuses on developing novel CD derivatives with improved physicochemical properties.

Purpose of the Study:

  • To investigate the physicochemical and self-associating characteristics of novel dextran-based cyclodextrin polymers.
  • To evaluate the impact of linkage type (ether vs. ester) and molecular weight on drug complexation.

Main Methods:

  • Phase-solubility studies were employed to assess drug solubilization.
  • Permeation studies evaluated drug transport.
  • Dynamic light scattering analyzed self-associating properties.

Main Results:

  • Solubilization and binding efficiency of hydrocortisone decreased with increasing polymer molecular weight.
  • Polymers with ether linkages demonstrated more favorable properties compared to ester linkages.
  • Self-association of drug-polymer complexes was observed, indicating potential instability.

Conclusions:

  • Dextran-based cyclodextrin polymers exhibit tunable properties based on molecular weight and linkage type.
  • Ether-linked polymers are more promising for pharmaceutical applications.
  • Further research is needed to address the instability of self-associated drug-polymer complexes.