Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

175
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
175
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

238
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
238
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

266
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
266
Obesity01:24

Obesity

1.2K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.2K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.0K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.0K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.0K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adrenal function, morbidity and mortality in patients with COVID-19.

Endocrine·2025
Same author

Influence of Sex and Age on Irisin Levels in Pediatric Type 1 Diabetes: A Pilot Study.

Journal of clinical medicine·2025
Same author

Cortisol Secretion in Obesity Revisited: Lower Basal Serum and Salivary Cortisol with Diminished Cortisol Response to the Low Dose ACTH Challenge.

Obesity facts·2025
Same author

Characterization of a Novel Variant in the NR3C1 Gene: Differentiating Glucocorticoid Resistance From Cushing Syndrome.

The Journal of clinical endocrinology and metabolism·2024
Same author

Treating late-onset Tay Sachs disease: Brain delivery with a dual trojan horse protein.

Molecular therapy. Methods & clinical development·2024
Same author

The circadian syndrome is a predictor for cognition impairment in middle-aged adults: Comparison with the metabolic syndrome.

Diabetes/metabolism research and reviews·2024
Same journal

Peripheral Nervous System Involvement in Parkinson's Disease: Peripheral Neuropathy, Neuromuscular Junction Dysfunction, and Clinical Implications.

Neuroscience and biobehavioral reviews·2026
Same journal

Violence on the self: Exploring the intersection of trauma and identity among sexual and gender minorities from a neurobiological and developmental perspective to advance our understanding of PTSD, moral injury, and dissociation symptoms.

Neuroscience and biobehavioral reviews·2026
Same journal

Meaning in life and biological functioning: A multisystem synthesis and agenda for future research.

Neuroscience and biobehavioral reviews·2026
Same journal

Beyond Diagnosis: Why and How Virtual Reality Should be Used in Research on Neurodevelopmental Conditions?

Neuroscience and biobehavioral reviews·2026
Same journal

What eye-movements tell us about Disorders of Consciousness?

Neuroscience and biobehavioral reviews·2026
Same journal

Systematic Review of Tactile-Based Interventions Combined with Multisensory Stimulation Protocols in the Rehabilitation of Patients with Disorders of Consciousness.

Neuroscience and biobehavioral reviews·2026
See all related articles

Related Experiment Video

Updated: Jan 26, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

958

Is obesity a brain disease?

Gabi Shefer1, Yonit Marcus, Naftali Stern

  • 1Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv, Israel.

Neuroscience and Biobehavioral Reviews
|August 6, 2013
PubMed
Summary
This summary is machine-generated.

Obesity involves brain changes, not just psychological factors. Excessive nutrition causes brain alterations, leading to a cycle of metabolic and cognitive issues, highlighting the brain

Keywords:
Cognitive declineHippocampusHypothalamic inflammationMemoryObesity

More Related Videos

Acupoint Catgut Embedding Therapy for Abdominal Obesity Treatment
05:18

Acupoint Catgut Embedding Therapy for Abdominal Obesity Treatment

Published on: November 22, 2024

1.4K
Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

12.6K

Related Experiment Videos

Last Updated: Jan 26, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

958
Acupoint Catgut Embedding Therapy for Abdominal Obesity Treatment
05:18

Acupoint Catgut Embedding Therapy for Abdominal Obesity Treatment

Published on: November 22, 2024

1.4K
Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

12.6K

Area of Science:

  • Neuroscience
  • Metabolic Disorders
  • Obesity Research

Background:

  • Obesity pathogenesis traditionally focused on psychological and environmental factors.
  • The brain's role in obesity is increasingly recognized beyond the 'it's all in the head' axiom.
  • Excessive caloric intake triggers biological changes impacting energy regulation.

Purpose of the Study:

  • To review evidence linking excessive nutrition to brain alterations in obesity.
  • To highlight structural and functional brain changes associated with obesity.
  • To emphasize the need for recognizing brain disease in obesity for therapeutic targeting.

Main Methods:

  • Review of existing scientific literature on obesity and brain function.
  • Analysis of studies reporting structural and functional brain changes in obese individuals.
  • Synthesis of evidence on the impact of caloric flux on neural circuits.

Main Results:

  • Excessive nutrition induces aberrant energy control circuits, worsening with increased body fat.
  • Recognized brain changes include hypothalamic inflammation, gliosis, reduced brain volume, and diminished hippocampal size.
  • These changes contribute to a cycle of metabolic dysfunction and cognitive deficits.

Conclusions:

  • The brain is integral to obesity pathogenesis and perpetuation, not merely a psychological component.
  • Obesity-induced brain disease is a critical factor requiring recognition for effective treatment.
  • Future therapies should consider targeting these neurobiological changes in obesity management.