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Published on: November 4, 2017
Pelvic axis-based gait analysis for ataxic mice
Naoki Takayanagi1, Hidehiko Beppu, Kenmei Mizutani
1Rehabilitation Medicine II, Graduate School of Medicine, Fujita Health University, Mie 514-1296, Japan. naoki-t@fujita-hu.ac.jp
Journal of Neuroscience Methods
|August 6, 2013
Summary
A new pelvic axis-based gait analysis method accurately assesses hind limb angles in mice with gait disorders. This method effectively differentiates ataxic and Parkinson
Area of Science:
- Neuroscience
- Animal Models
- Biomechanics
Background:
- Existing gait analysis methods are insufficient for mice with specific gait disorders.
- Accurate assessment of hind limb angle is crucial for understanding gait pathology.
Purpose of the Study:
- To develop and validate a novel gait analysis method for mice.
- To accurately measure hind limb angles based on the pelvic axis.
Main Methods:
- Video-recording gait of control (C57BL/6J) and ataxic mice (B6-wob/t, MPTP-treated, Ara-treated) from the ventral side.
- Establishing a pelvic axis-based limb angle measurement technique.
- Comparing the new method with the existing nose-tail method.
Main Results:
- Hind limb angles were significantly wider in ataxic and MPTP-treated mice compared to controls (p<0.01).
- The new method successfully differentiated between mouse groups using scatter plot analysis.
- The nose-tail method failed to differentiate between control and B6-wob/t mice, unlike the new method.
Conclusions:
- The pelvic axis-based gait analysis method is a promising and valid tool.
- This method is particularly useful for analyzing gait disorders in mice.
