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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

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Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
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Non-coding RNAs: multi-tasking molecules in the cell.

Anita Quintal Gomes1, Sofia Nolasco, Helena Soares

  • 1Health Technology College of Lisbon-Polytechnic Institute of Lisbon, 1990-096 Lisbon, Portugal. anita.gomes@estesl.ipl.pt

International Journal of Molecular Sciences
|August 6, 2013
PubMed
Summary
This summary is machine-generated.

Small non-coding RNAs (sncRNAs) and long noncoding RNAs (lncRNAs) are key regulators of gene expression and epigenetics. Their dysregulation is implicated in human diseases, including cancer.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Epigenetics

Background:

  • The mammalian transcriptome is complex, featuring numerous small non-coding RNAs (sncRNAs) and long noncoding RNAs (lncRNAs).
  • These noncoding RNAs (ncRNAs) are crucial for gene silencing, genome defense, and gene expression regulation.

Purpose of the Study:

  • To review the biogenesis pathways of sncRNAs (siRNAs, miRNAs, piRNAs) and lncRNAs.
  • To highlight the roles of sncRNAs and lncRNAs in differentiation, development, and epigenetics.
  • To discuss the implications of ncRNA deregulation in human diseases, particularly cancer.

Main Methods:

  • Literature review of sncRNA and lncRNA biogenesis pathways.
  • Analysis of ncRNA roles in gene regulation, epigenetics, differentiation, and development.
  • Examination of ncRNA involvement in human diseases.

Main Results:

  • Detailed review of biogenesis pathways for siRNAs, miRNAs, and piRNAs.
  • lncRNAs are pivotal in transcriptional and post-transcriptional gene regulation.
  • sncRNAs and lncRNAs significantly impact DNA methylation and chromatin remodeling, influencing epigenetics.
  • Overlapping pathways suggest concerted functions and complex regulatory networks involving proteins.

Conclusions:

  • sncRNAs and lncRNAs are essential regulators with critical roles in development and epigenetics.
  • Deregulation of sncRNA and lncRNA biogenesis and expression is linked to human diseases like cancer.
  • These ncRNAs likely function in complex, cooperative regulatory networks.