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Related Concept Videos

Fetal Circulation01:14

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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A Novel Surgical Approach for Intratracheal Administration of Bioactive Agents in a Fetal Mouse Model
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Published on: October 31, 2012

[Advances in fetal therapy].

Lucas Otaño1, César Hernán Meller, Horacio Aiello

  • 1Servicio de Obstetricia, Unidad de Medicina Fetal, Hospital Italiano de Buenos Aires, Argentina.

Archivos Argentinos De Pediatria
|August 6, 2013
PubMed
Summary

Fetal therapy, including pharmacotherapy and invasive procedures, aims to improve outcomes for newborns. This review updates knowledge on non-invasive and invasive fetal treatment options.

Area of Science:

  • Perinatal Medicine
  • Maternal-Fetal Medicine
  • Developmental Biology

Context:

  • Fetal therapy is crucial in specific clinical situations to enhance perinatal and long-term outcomes for fetuses and newborns.
  • Understanding different therapeutic approaches is essential for managing high-risk pregnancies.

Purpose:

  • To provide an updated overview of both non-invasive and invasive fetal therapies.
  • To highlight advancements and current practices in the field of fetal treatment.

Summary:

  • Fetal therapy encompasses pharmacotherapy (maternal drug administration crossing the placenta) and invasive methods (needles, fetoscopy, open surgery).
  • Non-invasive approaches focus on maternal treatment, while invasive therapies directly intervene on the fetus.
  • This review consolidates current knowledge on these diverse therapeutic strategies.

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Impact:

  • Improved understanding of fetal treatment options can lead to better clinical decision-making.
  • Advances in fetal therapy offer potential for improved survival and quality of life for affected newborns.
  • This review serves as a resource for clinicians and researchers in maternal-fetal medicine.