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Related Concept Videos

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
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Developing international consensus for late effects screening and guidance.

Rod Skinner1, Kevin C Oeffinger

  • 1Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK. Roderick.Skinner@ncl.ac.uk

Current Opinion in Supportive and Palliative Care
|August 6, 2013
PubMed
Summary
This summary is machine-generated.

Long-term follow-up (LTFU) for childhood cancer survivors is crucial due to chronic health issues. Pan-European and international groups are harmonizing guidelines to improve survivor care and outcomes.

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Area of Science:

  • Oncology
  • Public Health
  • Survivorship Care

Background:

  • Childhood cancer survivors face a high risk of serious, disabling, or life-threatening chronic medical problems.
  • Existing long-term follow-up (LTFU) guidelines vary, creating uncertainty regarding optimal care content and structure.
  • Addressing late effects is essential for improving survivors' long-term health and quality of life.

Purpose of the Study:

  • To review the importance and current state of long-term follow-up (LTFU) for childhood cancer survivors.
  • To highlight initiatives aimed at developing standardized and harmonized LTFU guidelines.
  • To address the need for consistent recommendations across diverse healthcare settings.

Main Methods:

  • Development of pan-European guidelines by the EU-funded PanCareSurFup project.
  • Efforts by the International Late Effects of Childhood Cancer Guideline Harmonization Group to achieve consensus.
  • Focus on prevention, early detection, treatment of late effects, and transitional care.

Main Results:

  • PanCareSurFup is creating guidelines for physical and psychosocial late effects, including transitional care and health promotion.
  • The Guideline Harmonization Group is working towards consensus on clinical practice for major late effects.
  • The goal is to produce harmonized recommendations applicable to various national contexts.

Conclusions:

  • These collaborative initiatives aim to standardize and enhance the efficiency of LTFU care.
  • The ultimate goal is to improve long-term health outcomes and quality of life for childhood cancer survivors.
  • Harmonized guidelines will provide valuable, consistent care recommendations for survivors globally.