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Updated: May 9, 2026

Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography
Published on: May 26, 2015
A blind spot in the eye of imaging technology: penetrating atheromatous ulcer
Jorge Romero1, Arpit Shah, Aleksandr Korniyenko
1Department of Internal Medicine, St Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York 10019, USA. jr2902@columbia.edu
Abstract:
Acute aortic syndrome (AAS) is a term that is used to describe a similar clinical profile that may have different underlying pathophysiological mechanisms. It includes classic aortic dissection, intramural aortic hematoma, and penetrating atherosclerotic ulcer. We describe the case of a 77-year-old female who presented with syncope of unknown duration. The chest X-ray was suggestive of a widened mediastinum. The initial work-up with a computed tomography scan and transesophageal echocardiogram failed to diagnose a penetrating atherosclerotic ulcer. We discuss the importance of a high degree of clinical suspicion for AAS and the utility of different imaging technologies in making the diagnosis.
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