Related Experiment Video
Updated: May 9, 2026

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
Published on: September 14, 2018
Pharmacokinetics and ADME characterizations of antibody-drug conjugates
Kedan Lin1, Jay Tibbitts, Ben-Quan Shen
1Early Development Pharmacokinetics and Pharmacodynamics, Genentech Inc., South San Francisco, CA, USA.
Abstract:
Pharmacokinetic and absorption, distribution, metabolism, and excretion (ADME) characterization of antibody-drug conjugates (ADCs) reflects the dynamic interactions between the biological system and ADC, and provides critical assessments in lead selection, optimization, and clinical development. Understanding the pharmacokinetics (PK), ADME properties and consequently the pharmacokinetic-pharmacodynamic properties of ADCs is critical for their successful development. This chapter discusses the PK properties of ADCs, types of PK and ADME studies in supporting different stages of development, general design of PK/ADME studies with a focus on ADC-specific characteristics, and interpretation of PK parameters.
More Related Videos
11:58Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting
Published on: March 8, 2018
08:47Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
Related Concept Videos
Measurement of Bioavailability: Pharmacokinetic Methods
Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding
To quantify the extent of bioavailability, pharmacologists often use a parameter called .
Pharmacokinetic–Pharmacodynamic Relationship: Problems
Measurement of Bioavailability: Pharmacodynamic Methods
Biopharmaceutics and Pharmacokinetics: Overview
Drug Distribution: Plasma Protein Binding