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Updated: May 9, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Coronary intervention on a moving target: a case report and procedural considerations
Ali Ali1, Sandeep S Hothi, Dominic Cox
1Heart Centre, Cliftonville, Northampton General Hospital, Northampton, United Kingdom NN1 5BD. drbukharian@hotmail.com
Insights
Mechanical chest compressions enabled successful coronary angiography and percutaneous coronary intervention (PCI) during cardiac arrest from ST-elevation myocardial infarction (STEMI). This approach maintained neurological function and survival, offering new possibilities for treating acute heart attacks.
Area of Science:
- Cardiology
- Emergency Medicine
- Interventional Cardiology
Background:
- Cardiac arrest, often caused by coronary disease, has high mortality and neurological sequelae among survivors.
- Early and effective resuscitation is crucial for improving outcomes in cardiac arrest patients.
- ST-elevation myocardial infarction (STEMI) leading to ventricular fibrillation (VF) cardiac arrest presents a critical therapeutic challenge.
Observation:
- A case of out-of-hospital STEMI and VF cardiac arrest is presented.
- Mechanical chest compressions were employed to support the patient during resuscitation.
- Coronary angiography and primary percutaneous coronary intervention (PCI) were performed during ongoing VF.
Findings:
- Mechanical chest compressions provided sufficient perfusion pressure to allow coronary angiography during VF.
- This facilitated successful primary PCI, a novel achievement during active cardiac arrest.
- The patient maintained neurological function and survived despite a 79-minute delay between arrest and PCI.
Implications:
- Mechanical chest compressions can facilitate life-saving interventional procedures during cardiac arrest.
- This case demonstrates the feasibility of primary PCI in STEMI patients experiencing VF arrest.
- Further research into the practical considerations and broader application of mechanical CPR in interventional cardiology is warranted.
Abstract:
Cardiac arrest carries a considerable mortality. Among survivors, the incidence of neurological dysfunction is considerable. Coronary disease is a major cause of cardiac arrest and early and effective resuscitation is related to outcome. We report for the first time a case of successful coronary angiography and primary percutaneous coronary intervention (PCI) during ongoing ventricular fibrillation (VF) supported by mechanical chest compressions following out-of-hospital ST-elevation myocardial infarction (STEMI) and VF cardiac arrest. It illustrates four novel findings permitted by the use of mechanical chest compressions: (1) that it provided a perfusion pressure that facilitated the act of coronary angiography during ongoing VF following out-of-hospital STEMI and VF arrest, which (2) in turn permitted successful primary PCI, with (3) maintained neurological function and survival despite 79 minutes between arrest and PCI, and (4) illustrates the practical considerations that one must consider for PCI during mechanical chest compressions.
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