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Updated: May 9, 2026
CO2-Lasertonsillotomy Under Local Anesthesia in Adults
Published on: November 6, 2019
Use of local mitomycin C in enhancing laryngeal healing after laser cordotomy: a prospective controlled study
Samya A Fawaz1, Sabri M Sabri, Ahmed S Sweed
1Department of Otorhinolaryngology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Background:
The purpose of this study was to investigate the role of intraoperative application of mitomycin C in prevention of glottic restenosis after posterior transverse CO2 laser cordotomy (PTLC) for patients with post-thyroidectomy bilateral vocal fold paralysis.
Methods:
Twenty-five patients with an impaired airway because of bilateral vocal fold paralysis were treated with PTLC. Patients were divided into groups: the mitomycin C group (13 patients) had PTLC and topical mitomycin C; and the control group (12 patients) had PTLC only.
Results:
No patients in the mitomycin C group developed glottic granulation or laryngeal scarring, whereas 5 of 12 patients in the control group developed granulation (p = .014) and 2 of 12 patients had laryngeal scarring (p = .28). Ten of 13 patients in the mitomycin C group ended up with mild dyspnea with no limitation to normal everyday activities whereas only a third of the control group achieved this outcome (p = .05).
Conclusion:
The use of topical mitomycin C has been shown to decrease postoperative laryngeal granulation, scarring, restenosis, and the need for revision surgery.
