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Updated: May 9, 2026

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Published on: April 18, 2019

Recent developments in methods for analysis of perfluorinated persistent pollutants.

Marek Trojanowicz¹, Mariusz Koc

¹Department of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland ; Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland.

Mikrochimica Acta

|August 6, 2013

Summary

This review details advancements in analyzing per- and polyfluoroalkyl substances (PFASs) in diverse samples. It compares various analytical methods and highlights the growing focus on branched isomers and total organic fluorine measurements.

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Area of Science:

Environmental Chemistry
Analytical Chemistry
Toxicology

Background:

Per- and polyfluoroalkyl substances (PFASs) are globally pervasive environmental contaminants found in ecosystems and biota.
Their persistence necessitates continuous improvement in analytical methodologies for accurate detection and quantification.
PFASs pose risks, driving research into their environmental fate and biological impact.

Purpose of the Study:

To review recent analytical achievements in PFAS determination across various matrices.
To compare different analytical methods for PFAS detection, including chromatography-mass spectrometry.
To assess the relationship between specific PFAS measurements and Total Organic Fluorine (TOF) levels.

Main Methods:

Chromatographic techniques, primarily High-Performance Liquid Chromatography (HPLC) and Gas Chromatography (GC), are dominant.

Keywords:

Gas chromatography Liquid chromatography Mass spectrometry PFOA PFOS Perfluoroalkyl substances Persistent organic pollutants

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Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique

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Last Updated: May 9, 2026

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Published on: April 18, 2019

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique

Published on: September 28, 2022

Mass spectrometry (MS) is the most common detector, often coupled with chromatography.

Alternative detectors include conductivity, fluorimetry, flame ionization, and electron capture detectors.

Main Results:

Significant progress has been made in determining a wide array of PFASs in environmental and biological samples.
Comparison of methods reveals varying sensitivities and specificities for different PFAS congeners.
Emerging research focuses on quantifying branched isomers and their prevalence in food matrices.

Conclusions:

Advanced analytical methods are crucial for understanding the global distribution and impact of PFASs.
Developing a comprehensive index for total PFAS content is essential for risk assessment.
Further research is needed on branched PFAS isomers, particularly in food, due to potential health implications.