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Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
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Cutaneous hemangiosarcoma in a dog.

Naho Tsuji1, Satoshi Furukawa, Kiyokazu Ozaki

  • 1Department of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.

Journal of Toxicologic Pathology
|August 6, 2013
PubMed
Summary
This summary is machine-generated.

A golden retriever developed multiple masses diagnosed as hemangiosarcoma with lymphatic differentiation. This vascular tumor showed characteristics of both blood and lymphatic endothelial cells.

Keywords:
caninehemangiosarcomalymphangiosarcoma

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Area of Science:

  • Veterinary Pathology
  • Canine Oncology
  • Surgical Oncology

Background:

  • Cutaneous and subcutaneous masses are common in dogs.
  • Hemangiosarcoma is a malignant vascular tumor that can occur in various tissues.
  • Lymphatic differentiation in vascular tumors is rare and requires specific diagnostic markers.

Purpose of the Study:

  • To diagnose and characterize multiple cutaneous and subcutaneous masses in a golden retriever.
  • To investigate the histopathological and immunohistochemical features of the tumor.
  • To determine if the tumor exhibits lymphatic endothelial cell differentiation.

Main Methods:

  • Histopathological examination of excised tumor masses.
  • Immunohistochemical staining for CD31 (endothelial marker) and PROX-1 (lymphatic endothelial cell marker).

Main Results:

  • Histopathology revealed multiple tumor foci from the dermis to subcutaneous tissue with vascular, alveolar, and solid patterns.
  • Neoplastic cells showed features of both mature endothelium and large pleomorphic cells.
  • Immunohistochemistry showed strong positivity for CD31 and frequent positivity for PROX-1.

Conclusions:

  • The tumor was diagnosed as hemangiosarcoma with lymphatic differentiation based on combined histopathological and immunohistochemical findings.
  • This case highlights the importance of immunohistochemistry in diagnosing complex vascular tumors.
  • The presence of lymphatic differentiation suggests a potential for unique biological behavior and treatment considerations.