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Updated: May 9, 2026

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Published on: December 15, 2023

Universal antenatal screening for hepatitis C.

J Lambert¹, V Jackson, S Coulter-Smith

¹Rotunda Hospital, Parnell St, Dublin. jlambert@mater.ie

Irish Medical Journal

|August 7, 2013

Summary

This summary is machine-generated.

Universal antenatal hepatitis C virus (HCV) screening identified a 0.9% seroprevalence in pregnant women. A significant number of positive cases lacked identifiable risk factors, highlighting the need for broad screening strategies.

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Published on: December 15, 2023

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

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Published on: February 1, 2017

Area of Science:

Hepatology
Infectious Diseases
Public Health

Background:

Hepatitis C virus (HCV) infection poses a significant global health challenge.
Accurate seroprevalence data in specific populations, like pregnant women, is crucial for targeted interventions.
Previous screening methods often relied on risk assessment, potentially missing undiagnosed cases.

Purpose of the Study:

To evaluate the feasibility of implementing universal antenatal screening for HCV.
To determine the true seroprevalence of HCV infection among an unselected antenatal population.
To identify risk factors associated with HCV infection in this demographic.

Main Methods:

A prospective study involving universal antenatal screening for HCV antibodies.
Administration of a risk assessment questionnaire to all women attending antenatal care.
Analysis of serological testing results and questionnaire data from a large cohort.

Main Results:

High uptake of 98.4% for universal screening among 8976 participants.
Identified an anti-HCV antibody positive seroprevalence of 0.9% (78 women).
A substantial proportion (27%) of anti-HCV positive women reported no identifiable risk factors.

Conclusions:

Universal antenatal HCV screening is a feasible and effective strategy for identifying infections.
The calculated seroprevalence of 0.9% underscores the importance of screening in this population.
The absence of identifiable risk factors in a significant minority of cases supports a universal screening approach over risk-based selection.