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Fatal cardiac and renal allograft rejection with lenalidomide therapy for light-chain amyloidosis
D E Meyers1, B Adu-Gyamfi, A M Segura
1Department of Cardiology, Advanced Heart Failure and Transplantation, Texas Heart Institute, Houston, TX.
Abstract:
We describe a patient who underwent a successful heart and kidney transplant for light-chain amyloidosis. She had an excellent hematologic response to bortezomib/dexamethasone therapy. Follow-up therapy with lenalidomide was started, and the patient quickly had a fatal allograft rejection of the heart and kidney. We present evidence to support the theory that lenalidomide, a known immunomodulator, may have stimulated the immune system and precipitated the fatal rejection episode.
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