Related Experiment Video
Updated: May 9, 2026
07:13
Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
Published on: May 16, 2022
Raman spectroscopy in nanomedicine: current status and future perspective
1Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin 8, Ireland. mark.keating@mydit.ie
Nanomedicine (London, England)
|August 7, 2013
Summary
Raman spectroscopy, a vibration spectroscopy technique, offers advanced chemical analysis for materials. Enhanced Raman microscopy applications now span medical diagnostics and nanomaterial-biomaterial interfaces, showing great potential.
Area of Science:
- Analytical Chemistry
- Spectroscopy
- Nanotechnology
Background:
- Raman spectroscopy probes material chemical composition using vibration spectroscopy.
- Advances in Raman microscopy expand applications from medical diagnostics to nanomaterial interfaces.
- It offers advantages over other analytical techniques.
Purpose of the Study:
- To review Raman spectroscopy's past successes and benefits.
- To describe nanoscale Raman techniques like surface- and tip-enhanced Raman spectroscopy (SERS/TERS).
- To explore applications in nanomedicine and label-free nanoscale investigations.
Main Methods:
- Review of existing literature on Raman spectroscopy and its advanced forms.
- Focus on surface-enhanced Raman spectroscopy (SERS) and tip-enhanced Raman spectroscopy (TERS).
- Exploration of coherent anti-Stokes Raman scattering (CARS) for biomedical applications.
Main Results:
- Raman spectroscopy provides detailed chemical information.
- Enhanced Raman techniques (SERS, TERS) enable nanoscale chemical probing.
- Coherent anti-Stokes Raman scattering shows promise in biomedical fields.
Conclusions:
- Raman spectroscopy is a versatile tool for chemical analysis.
- Advanced Raman methods significantly enhance nanoscale and biomedical investigations.
- The technique holds substantial potential for future nanomedical applications.
Related Concept Videos
01:20Raman Spectroscopy: Overview
The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and the...
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and the...
01:26Raman Spectroscopy Instrumentation: Overview
A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
01:25Applications Of NMR In Biology
Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
The...
The...
01:07Nuclear Magnetic Resonance (NMR): Overview
Nuclear magnetic resonance (NMR) is a phenomenon exhibited by certain nuclei that can absorb characteristic radio frequency radiation under certain conditions. NMR has been extensively applied in molecular spectroscopy and medical diagnostic imaging. In both these applications, the molecule or subject under study is placed in a magnetic field and irradiated with radio frequency energy.
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...