Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...

Kidney Transplant II: Surgical Procedure

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

Kidney Transplant III: Nursing Management

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Once-weekly semaglutide 7·2 mg in adults with obesity (STEP UP): a randomised, controlled, phase 3b trial.

The lancet. Diabetes & endocrinology·2025

Same author

Transcatheter or surgical aortic valve implantation: 10-year outcomes of the NOTION trial.

European heart journal·2024

Same author

Effects of Semaglutide on Albuminuria and Kidney Function in People With Overweight or Obesity With or Without Type 2 Diabetes: Exploratory Analysis From the STEP 1, 2, and 3 Trials.

Diabetes care·2023

Same author

Two-year effect of semaglutide 2.4 mg on control of eating in adults with overweight/obesity: STEP 5.

Obesity (Silver Spring, Md.)·2023

Same author

Effects of once-weekly semaglutide 2.4 mg on C-reactive protein in adults with overweight or obesity (STEP 1, 2, and 3): Exploratory analyses of three randomised, double-blind, placebo-controlled, phase 3 trials.

EClinicalMedicine·2022

Same author

Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial.

Nature medicine·2022

Search research articles

Related Experiment Video

Updated: May 9, 2026

Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration

Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration

Published on: June 7, 2014

Renal replacement therapy after cardiac surgery; renal function recovers.

Kristin Julia Steinthorsdottir¹, Kristian Kandler, Nis Agerlin Windeløv

¹Department of Cardiothoracic Surgery, Rigshospitalet, Copenhagen University Hospital , Copenhagen , Denmark.

Scandinavian Cardiovascular Journal : SCJ

|August 7, 2013

Summary

Patients recovering from cardiac surgery-associated acute kidney injury (CSA-AKI) and needing renal replacement therapy showed good renal outcomes after hospital discharge. Most patients did not require further renal replacement therapy, indicating significant kidney function recovery.

More Related Videos

Normothermic Machine Perfusion of Rat Kidneys for Transplantation

Normothermic Machine Perfusion of Rat Kidneys for Transplantation

Published on: January 27, 2026

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

Related Experiment Videos

Last Updated: May 9, 2026

Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration

Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration

Published on: June 7, 2014

Normothermic Machine Perfusion of Rat Kidneys for Transplantation

Normothermic Machine Perfusion of Rat Kidneys for Transplantation

Published on: January 27, 2026

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

Area of Science:

Nephrology
Cardiology
Critical Care Medicine

Background:

Cardiac surgery-associated acute kidney injury (CSA-AKI) is a significant complication.
Renal replacement therapy (RRT) is sometimes required for severe CSA-AKI.
Long-term renal outcomes for patients with CSA-AKI treated with RRT are not well-established.

Purpose of the Study:

To evaluate the renal outcomes of patients discharged from hospital after CSA-AKI requiring RRT.
To determine the need for subsequent RRT and serum creatinine levels at follow-up.

Main Methods:

A cross-sectional study was conducted on adult patients who underwent cardiac surgery between 2008-2010 and received RRT.
Inclusion criteria included pre-operative serum creatinine (sCr) < 200 μM and survival to discharge.
Primary endpoint: need for RRT post-discharge. Secondary endpoint: sCr > 200 μM at follow-up.

Main Results:

Out of 3828 cardiac surgery patients, 107 received post-operative RRT for CSA-AKI, with 70 surviving to discharge.
At follow-up (median sCr 111 μM), 56 patients were alive.
None required further RRT, and only 2 (4%) had sCr > 200 μM.

Conclusions:

Renal function generally recovered in patients discharged after CSA-AKI requiring RRT.
No patients required re-initiation of RRT post-discharge.
A low percentage of patients exhibited elevated serum creatinine levels at follow-up.