Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Personality Disorders: Dependent and Obsessive-Compulsive01:24

Personality Disorders: Dependent and Obsessive-Compulsive

Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
 Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle with...
Self-Discrepancy Theory02:45

Self-Discrepancy Theory

One influential perspective on what motivates people's behavior is detailed in Tory Higgin's self-discrepancy theory (Higgins, 1987). He proposed that people hold disagreeing internal representations of themselves that lead to different emotional states.
Self-Discrepancy and Its Effects01:29

Self-Discrepancy and Its Effects

Self-discrepancy theory explains how people compare their actual self to their ideal and ought selves and how mismatches between these self-guides can lead to emotional distress. Developed by E. Tory Higgins, the theory distinguishes among three components of self-concept: the actual self, the ideal self, and the ought self. These refer respectively to how individuals perceive themselves, how they aspire to be, and how they believe they are obligated to be. Emotional well-being, self-esteem,...
Anorexia Nervosa01:28

Anorexia Nervosa

Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contextualizing racial differences in baseline neuropsychological assessment of collegiate athletes.

Journal of the International Neuropsychological Society : JINS·2026
Same author

Symptom clusters and cognitive changes: predictors of recovery timelines following concussion in college athletes.

Journal of clinical and experimental neuropsychology·2026
Same author

Quality of Life, Self-Reported Cognitive Difficulties, and Performance-Based Cognitive Problems in Multiple Sclerosis: What's Sleep Got to Do With It?

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists·2026
Same author

Get Your Brain in the Game: Using Machine Learning to Predict Recovery Timelines Following Sports-Related Concussion.

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists·2025
Same author

Depressive Symptoms, Sleep Complaints, and Cognitive Performance: Examining the Mediating Role of Sleep in College Athletes.

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists·2025
Same author

Coping is a moderator of relationships between cognitive fatigue and cognitive variability in multiple sclerosis.

Journal of the International Neuropsychological Society : JINS·2025

Related Experiment Video

Updated: May 9, 2026

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Perfectionism and physical disability predict depression in multiple sclerosis.

Megan M Smith1, Peter A Arnett

  • 1Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1000, USA. megan-m-smith@uiowa.edu

Journal of Psychosomatic Research
|August 7, 2013
PubMed
Summary

Perfectionism exacerbates depression in multiple sclerosis (MS) patients with high physical disability. This finding helps explain varied depression levels in MS and suggests psychotherapy targets.

Keywords:
DepressionMultiple sclerosisNeuropsychologyPhysical disability

More Related Videos

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

Related Experiment Videos

Last Updated: May 9, 2026

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Psychology

Background:

  • The link between depression and physical disability in multiple sclerosis (MS) remains poorly understood.
  • Existing research presents conflicting findings on this relationship.

Purpose of the Study:

  • To investigate the interplay between disability and perfectionism in predicting depression among individuals with MS.
  • To clarify the factors influencing depression in MS patients.

Main Methods:

  • Fifty-one participants with MS completed the Frost Multidimensional Perfectionism Scale (FMPS), Chicago Multiscale Depression Inventory (CMDI), and Expanded Disability Status Scale (EDSS).
  • Regression analyses were employed to examine predictive relationships.

Main Results:

  • A significant interaction between perfectionism (FMPS) and physical disability (EDSS) was found to predict depression (CMDI) beyond individual effects.
  • Perfectionism emerged as a significant predictor of depression specifically in individuals with high levels of physical disability.

Conclusions:

  • The study reconciles inconsistent findings on physical disability and depression in MS by highlighting the moderating role of perfectionism.
  • Identifying perfectionism as a key factor in high-disability MS patients offers a potential target for tailored psychotherapy interventions.